MISTRAL aims at boosting the Blue Growth sector in the MED area through an open innovation approach, since it recognizes that today the current innovation performance in this sector is behind the EU average and there is a lack of transnational cooperation. We aim to strengthen a transnational partnership in order to: make marine knowledge and sustainable innovation the key drivers for Blue Growth, support MED clusters to become an excellent intermediary of knowledge for increasing blue economy, design and implement sustainable development trajectories harmonized with the MED regions Smart Specialization Strategies. We have the ambition to develop a wider governance vision towards 2022 in the Blue Growth sector providing an effective policy mainstreaming and to be the Blue Innovation wind in the MED area by unlocking the innovation potentials of the Blue Ecosystem.